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KMID : 1094720110160050937
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Biotechnology and Bioprocess Engineering
2011 Volume.16 No. 5 p.937 ~ p.945
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Antibacterial activity of a sulfated galactan extracted from the marine alga Chaetomorpha aerea against Staphylococcus aureus
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Pierre Guillaume
Sopena Valerie
Juin Camille
Mastouri Amira
Graber Marianne
Maugard Thierry
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Abstract
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The in vitro antimicrobial activity of the marine green algae Chaetomorpha aerea was investigated against gram-positive bacteria, gram-negative bacteria, and a fungus. The water-soluble extract of algae was composed of a sulfated (6.3%) galactan with a molecular weight of 1.160 × 106 Da and a global composition close to commercial polysaccharides, such as dextran sulfate or fucoidan. The polysaccharide was composed of 18% arabinose, 24% glucose, and 58% galactose. The re-suspended extracts (methanol, water) exhibited selective antibacterial activities against 3 gram-positive bacteria including Staphylococcus aureus (ATCC 25923). Minimum inhibitory concentration and minimum bactericidal concentration tests showed that the sulfated galactan could be a bactericidal agent for this strain (40 mg/mL). The results of this study confirmed the potential use of the green algae Chaetomorpha aerea as a source of antibacterial compounds.
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KEYWORD
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seaweed, Chaetomorpha aerea, sulfated galactan, antibacterial activity, Staphylococcus aureus
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